Dr. Fortunatus C. Ezebuo is currently a faculty member in the Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka. Before he joined Nnamdi Azikiwe University, he served as a faculty member in the Department of Biochemistry, College of Natural and Applied Sciences, Chrisland University, Abeokuta from October, 2018 to March, 2019. Again, he worked as voluntary research/teaching assistant at the Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University from March, 2012 to November, 2018. Fortunatus is married to Goodness Ezebuo.

My current research interest focuses on computer-aided drug design/discovery for neglected tropical diseases/conditions especially schistosomiasis, emerging/re-emerging diseases especially ebola virus, lassa virus and flaviviruses, cancer, effects of amino acid mutations on proteins. The drug design/discovery efforts make use of approaches like molecular docking simulations, molecular dynamics simulations, sequence analysis, chemoinformatics etc. In particular, I am interested in using these methods/approaches for structure-based drug design and elucidation of molecular mechanism of receptor-ligand interactions. Available state-of-the-art computational software for this type of computations include GROMACS, VMD, PyMol, LigPlot+, AutodockVina, Dataworrior, in-house programs and other miscellaneous programs. I am also collaborating with experts (For example, Daniel Růžek and his team, https://www.paru.cas.cz/en/staff/profile/71/) with track records in wet-laboratory for validation of computer predicted findings.

Research Grants I am involved in are:
1. Research Assistant: Drug Repurposing for Lassa Fever Virus: A New Treatment Option. National Research Fund (NRF), 2019 Grant. Thirty-five million naira (N 35, 000, 000) only. Grant Number: TETFund/DR&D/CE/NRF/STI/24/VOL1. Year of study: 2020 – 2021. PI: Ikemefuna C. Uzochukwu

Also, I have received several awards/travel/research support grants including:
1. An European Molecular Biology Laboratory (EMBL) Corporate Partnership Programme Registration Fee Waive to participate in virtual EMBL Course: Computing Skills For Reproducible Research: Software Carpentry from 19-23 October 2020 organized by EMBL, Heidelberg, Germany

2. Travel/support grant to participate in School and Workshop on Plasmids as Vehicles of Antimicrobial Resistance Spread organized by the International Centre for Theoretical Physics (ICTP) and supposed to hold between 24 February 2020 - 6 March, 2020 in Trieste, Italy

3. Travel/support grant to participate in ICTS-ICTP Winter School on Quantitative Systems Biology (QSB2017) organized by International Centre for Theoretical Physics (ICTP), Italy in collaboration with International Centre for Theoretical Sciences (ICTS) of the Tata Institute of Fundamental Research (TIFR), Bangalore, India held from 04 to 22 December, 2017 at the ICTS campus, Bangalore, India

4. Travel/support grant to participate in DrosAfrica-ICGEB Workshop on Drosophila melanogaster in Biomedical Research: Low-Cost and Profitable held from 17 - 29 July, 2017, at University of Ibadan, Ibadan, Nigeria

5. Travel/support grant to participate in 5th Workshop on Advanced Techniques for Scientific Programming and Management of Open Source Software Packages” organized by the International Centre for Theoretical Physics (ICTP), Italy in collaboration with Sharif University of Technology, Tehran, Iran held between 4 – 15th March, 2017 in Tehran, Iran.

6. Best abstract award (Pharmaceutical Chemistry) during the 18th National Scientific Conference (Virtual) of Nigeria Association of Pharmacists in Academia (NAPA) held at University of Nigeria, Nsukka from 24th - 26th August, 2020

7. Best Poster award during Drug Discovery and Pathogen Box Conference & Workshop held from 4th-6th July, 2018 at Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Undergraduate Qualifications
Postgraduate Qualifications
M.Sc, PhD
Books Published
1. Ezebuo F.C., Kushwaha P.P., Singh A.K., Kumar S., Singh P. (2019) In-silico Methods of Drug Design: Molecular Simulations and Free Energy Calculations. In: Kumar S., Egbuna C. (eds) Phytochemistry: An in-silico and in-vitro Update. Springer, Singapore pp 521-533 https://doi.org/10.1007/978-981-13-6920-9_28

2. Ezebuo, F.C. (2010) Basic Laboratory Practices. Spingfield Publishers Ltd. Owerri ISBN: 978-8405-63-4

Selected Publications
1. Ezebuo, F.C., and Uzochukwu, I.C (2020) Drug Repurposing for Schistosomiasis: Molecular Docking and Dynamics Investigations. Journal of Biomolecular Structure and Dynamics 14:1-15. https://pubmed.ncbi.nlm.nih.gov/32924851/

2. Ezebuo, FC and Uzochukwu IC (2020) Schistosomal Sulfotransferase Interaction with Oxamniquine Involves Hybrid Mechanism of Induced-fit and Conformational Selection. Curr. Comput. Aided Drug Des. 16(4):451-459 https://pubmed.ncbi.nlm.nih.gov/31284869/

3. Stefanik, M., Valdes, J.J., Ezebuo, F.C., Haviernik, J., Uzochukwu, I.C., Fojtikova, M., Salat, J., Ludek Eyer, L and Ruzek, D (2020) FDA-approved drugs efavirenz, tipranavir, and dasabuvir inhibit replication of multiple flaviviruses in Vero cells. Microorganisms 2020, 8(4), 599; https://pubmed.ncbi.nlm.nih.gov/32326119/

4. Uzochukwu IC., Olubiyi, OO., Ezebuo, FC., Obinwa, IC., Ajaegbu, EE., 1 Eze, PM., Orji, CE., Onuoha, MC., Ejiofor, II and Nkechukwu, M (2016) Ending the Ebola Virus Scourge: A Case for Natural Products. J Pharm Res 1(1): 000105 https://medwinpublishers.com/OAJPR/OAJPR16000105.pdf

5. Ezebuo F. C., Lukong C.B., Uzochukwu, I. C, Okafor I.N (2016) In silico investigations revealed four potential colon cancer drugs from phytochemicals in Zingiber officinale. International Journal of Phytomedicine 8 (2016) 435 -443. http://dx.doi.org/10.5138/09750185.1886

6. Ezebuo, F.C., Eze S.O.O Lukong, C.B and Chilaka, F.C (2013) Interaction of Normal and Sickle Hemoglobins for Sodium Dodecylsulphate and Hydrogen Peroxide at pH 5.0 and 7.2 ISRN Haematology 2013: 1 -5, https://www.ncbi.nlm.nih.gov/pubmed/24224093
Previous Employment
1. Lecturer II, Department of Biochemistry, College of Natural and Applied Sciences, Chrisland University, Owode, Abeokuta, Ogun State, Nigeria, Oct., 2018 – March, 2019.

2. Voluntary teaching/research assistant, Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, March, 2012 – September, 2018